TPO, a lineage-specific growth factor, originates from the liver, kidney, and skeletal muscle. It triggers the growth and development of megakaryocytes, leading to higher platelet levels in the bloodstream. TPO communicates through the c-mpl receptor, playing a crucial role in platelet regulation. Both human and murine TPO can interact across species. The Recombinant Murine TPO, comprising 174 amino acids (18.7 kDa), is biologically active, encompassing the erythropoietin-like domain of the complete TPO protein.
$560.00 – $4,600.00
Product Specifications
Species Mouse
Published species
Human, Mouse, Rat
Expression System E. coli
Amino acid sequence SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF
Molecular weight 18.7 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <1 EU/µg
Activity
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
Conjugate Unconjugated
Form Lyophilized
Contains
no preservative
Storage conditions -20°C
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