CultureGro™ Human IL-10

Name: CultureGro™ Human IL-10 - Cell Culture Collective
SKU: CultureGro™ Human IL-10
Availability: InStock

$650.00

IL-10, an immunosuppressive cytokine, is synthesized by various mammalian cell types like macrophages, monocytes, T cells, B cells, and keratinocytes. Its primary function is to dampen the expression of proinflammatory cytokines such as IL-1 and TNF-α. Similar to IL-4, IL-10 boosts humoral immune responses while tempering cell-mediated immune reactions.

Interestingly, Human IL-10 exhibits activity on murine cells, but the reverse is not true—murine IL-10 doesn’t affect Human cells. The recombinant Human IL-10, a protein weighing 18.6 kDa and comprising 161 amino acid residues, reflects these immunomodulatory properties.

Volume

100ug
1mg
500ug
50ug

SKU CultureGro™ Human IL-10 Categories Cytokines, Recombinant Proteins

Product Details

Product Specifications Species Human Published species Human, Virus Expression System E. coli Amino acid sequence MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N Molecular weight 18.6 kDa Class Recombinant Type Protein Purity ≥ 98% by SDS-PAGE gel and HPLC analyses. Endotoxin concentration <0.1 EU/µg Activity Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg. Conjugate Unconjugated Form Lyophilized Contains no preservative Storage conditions -20°C

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