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IL-10, an immunosuppressive cytokine, is synthesized by various mammalian cell types like macrophages, monocytes, T cells, B cells, and keratinocytes. Its primary function is to dampen the expression of proinflammatory cytokines such as IL-1 and TNF-α. Similar to IL-4, IL-10 boosts humoral immune responses while tempering cell-mediated immune reactions.
Interestingly, Human IL-10 exhibits activity on murine cells, but the reverse is not true—murine IL-10 doesn’t affect Human cells. The recombinant Human IL-10, a protein weighing 18.6 kDa and comprising 161 amino acid residues, reflects these immunomodulatory properties.
Product Specifications
Species Human
Published species Human, Virus
Expression System E. coli
Amino acid sequence
MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Molecular weight 18.6 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg
Activity
Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.
Conjugate Unconjugated
Form Lyophilized
Contains
no preservative
Storage conditions -20°C
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