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CultureGro™ Human IL-1 alpha

CultureGro™ Human IL-1 alpha

IL-1α is a proinflammatory cytokine that is not secreted; it is produced by various cells like monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and share similar, if not identical, biological properties. These cytokines have diverse effects, including stimulating thymocyte proliferation by triggering IL-2 release, fostering B-cell maturation and proliferation, exhibiting mitogenic FGF-like activity, and prompting the release of prostaglandin and collagenase from synovial cells.

However, there is a notable difference: IL-1β is secreted, while IL-1α primarily remains associated with cells. The recombinant Human IL-1α is an 18.0 kDa protein comprising 159 amino acid residues.

$510.00$4,200.00

SKU CultureGro™ Human IL-1 alpha Categories ,

Product Details

Product Specifications

Species Human
Published species
Human, Mouse
Expression System E. coli
Amino acid sequence
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Molecular weight 18 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg Activity Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is ≤0.001 ng/ml, corresponding to a specific activity of ≥1 x 10^9 units/mg. Conjugate Unconjugated Form Lyophilized Contains no preservative Storage conditions -20°C