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CultureGro™ Human Activin-A Recombinant Protein Animal Free
Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in Human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.
The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
CultureGro™ Human Activin-A Recombinant Protein Animal Free
Species: Human, Mouse, Rat
Published species: Human, Mouse, Rat
Expression System: E. coli
Amino acid sequence:
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Molecular weight: 26 kDa
Class: Recombinant
Type: Protein
Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration: <0.1 EU/µg
Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.
Conjugate: Unconjugated
Form: Lyophilized
Purification: HPLC, SDS-PAGE
Contains no preservative
Storage conditions: -20°C
CAUTION: For Research Use Only. Not for use in diagnostic procedures.
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