CultureGro™ Human TPO Recombinant Protein, Animal Free

Thrombopoietin (TPO) is a crucial growth factor specifically generated in the liver, kidney, and skeletal muscle. It is essential for the proliferation and development of megakaryocytes, leading to an increase in circulating platelet levels in the body. TPO operates through the c-mpl receptor, playing a pivotal role in maintaining platelet numbers in the bloodstream. Notably, TPO from humans and mice is capable of cross-species interaction. The human TPO gene produces a 353 amino acid glycoprotein, inclusive of a 21 amino acid signal sequence, a 15 amino acid segment akin to the erythropoietin domain, and a significantly glycosylated 179 amino acid sequence at the C-terminal. The recombinant form of Human TPO, a fully active 174 amino acid polypeptide (18.6 kDa), incorporates the erythropoietin-like domain found in the full-length TPO protein, showcasing its bioactive potential.