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Flt3-Ligand is a growth factor responsible for regulating the proliferation of early hematopoietic cells. It binds to cells expressing the Flt3 tyrosine kinase receptor. Interestingly, Flt3-Ligand itself doesn’t directly stimulate the proliferation of early hematopoietic cells. Instead, it works synergistically with other colony-stimulating factors (CSFs) and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand doesn’t affect mast cells.
Various isoforms of Flt3-Ligand have been identified, with the predominant biologically active form being anchored to the cell surface as part of a transmembrane protein (209 amino acids). This membrane-bound isoform can undergo proteolytic cleavage, producing a biologically active soluble isoform.
Recombinant Human Flt3-Ligand is a soluble protein weighing 17.6 kDa and composed of 155 amino acid residues.
Product Specifications
Species: Human
Published Species: Hamster, Human, Mouse, Rabbit
Expression System: E. coli
Amino Acid Sequence: TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA
Molecular Weight 17.6 kDa
Class: Recombinant
Type: Protein
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Concentration: <0.1 EU/µg
Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human AML5 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.
Conjugate: Unconjugated
Form: Lyophilized
Contains no preservative
Storage conditions -20°C
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