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IL-15 serves as an immunomodulatory cytokine that triggers the growth of T lymphocytes, sharing numerous traits with IL-2. Its primary effects are directed towards T cells, aiding in their development, longevity, and activation. Moreover, IL-15 plays a crucial role in nurturing and activating natural killer (NK) cells. Elevated IL-15 levels have been associated with conditions such as rheumatoid arthritis, inflammatory bowel disease, and diseases linked to retroviruses like HIV and HTLV-I.
In experiments, Human IL-15 has demonstrated biological activity on mouse cells, notably by stimulating the dose-dependent proliferation of mouse CTLL cells. This recombinant protein, consisting of 115 amino acid residues and weighing 12.9 kDa, mirrors these functions.
Product Specifications
Species Human
Published species
Hamster, Human, Mouse
Expression System E. coli
Amino acid sequence
MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
Molecular weight 12.9 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg
Activity
Determined by its ability to stimulate the proliferation of mouse CTLL-2 cells. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10^6 units/mg.
Conjugate Unconjugated
Form Lyophilized
Contains
no preservative
Storage conditions -20°C
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