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$560.00
CultureGro™ Human TPO Recombinant Protein, Animal Free
Thrombopoietin (TPO) is a crucial growth factor specifically generated in the liver, kidney, and skeletal muscle. It is essential for the proliferation and development of megakaryocytes, leading to an increase in circulating platelet levels in the body. TPO operates through the c-mpl receptor, playing a pivotal role in maintaining platelet numbers in the bloodstream. Notably, TPO from humans and mice is capable of cross-species interaction.
The human TPO gene produces a 353 amino acid glycoprotein, inclusive of a 21 amino acid signal sequence, a 15 amino acid segment akin to the erythropoietin domain, and a significantly glycosylated 179 amino acid sequence at the C-terminal. The recombinant form of Human TPO, a fully active 174 amino acid polypeptide (18.6 kDa), incorporates the erythropoietin-like domain found in the full-length TPO protein, showcasing its bioactive potential.
CultureGro™ Human TPO Recombinant Protein, Animal Free
Species: Human
Expression System: E. coli
Amino acid sequence:
SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
Molecular weight: 18.6 kDa
Class: Recombinant
Type: Protein
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration: <0.1 EU/µg
Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.
Conjugate: Unconjugated
Form: Lyophilized
Purification: HPLC, SDS-PAGE
Contains: no preservative
Storage conditions: -20°C
CAUTION: For Research Use Only. Not for use in diagnostic procedures.
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