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CultureGro™ Human IL-6

CultureGro™ Human IL-6

IL-6 is a multifaceted cytokine pivotal in host defense, orchestrating immune and inflammatory responses. It’s generated by T cells, monocytes, fibroblasts, endothelial cells, and keratinocytes, showcasing a wide array of biological functions. IL-6 promotes B cell differentiation and antibody production, collaborates with IL-3 in megakaryocyte development and platelet production, triggers the expression of hepatic acute-phase proteins, and governs bone metabolism.

IL-6 communicates through the IL-6 receptor system composed of two chains: IL-6Rα and gp130. Notably, murine IL-6 lacks activity on Human cells, while both Human and murine variants are equally effective on murine cells. The recombinant Human IL-6 is a 20.9 kDa protein encompassing 184 amino acid residues.

$390.00$3,200.00

SKU CultureGro™ Human IL-6 Categories ,

Product Details

Product Specifications

Species Human
Published species
Human, Mouse
Expression System E. coli
Amino acid sequence
PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Molecular weight 20.9 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg Activity Determined by its ability to stimulate the proliferation of mouse B9 cells. Conjugate Unconjugated Form Lyophilized Contains no preservative Storage conditions -20°C