Original price was: $525.00.$367.50Current price is: $367.50.
CultureGro™ Human VEGF 165 Recombinant Protein, Animal Free
Vascular Endothelial Growth Factor (VEGF) is a vital glycoprotein composed of two identical units, each weighing 45 kDa and connected by disulfide bonds. It is pivotal in angiogenesis, which is essential for tumor growth and the spread of cancer. VEGF notably influences vascular endothelium by supporting endothelial cell survival, stimulating cell division, attracting cells (chemotaxis), and enhancing the ability of blood vessels to permeate substances. The VEGF family includes several members: VEGF-A through E and PlGF, all of which are key to the regulation of angiogenesis via cell signaling. This process is critical for virtually all tumors, with VEGF being the most significant cytokine driving angiogenesis. The production of five VEGF isoforms through the alternative splicing of a single VEGF gene allows for their interaction with two specific receptors, flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which are mainly found on endothelial cells. These interactions are crucial for the formation of blood vessels during embryonic development. The tyrosine kinases FLK1 and FLT1, alongside VEGF, play indispensable roles in this developmental stage. Furthermore, soluble FLT1 acts as a natural inhibitor of angiogenesis by binding to VEGF with high affinity. High levels of VEGF are associated with POEMS syndrome, also known as Crow-Fukase syndrome, a complex condition that affects multiple organs across the body.
Original price was: $515.00.$360.50Current price is: $360.50.
In the intricate world of cell culture, precision is everything. Monitoring plays a pivotal role in ensuring that cells thrive, experiments succeed, and data remains reliable. However, for many researchers, this critical aspect often becomes a source of frustration. From contamination to data inconsistencies, the challenges of cell culture monitoring
A future where new drugs are developed faster, safer, and with greater precision—without relying on animal testing or lengthy clinical trials. A future where treatments are tailored specifically to your genetic makeup, providing maximum efficacy with minimal side effects. This is the promise of 3D bioprinting in drug discovery, a
Imagine a future where your favourite burger doesn’t come from a farm but a lab—produced without slaughter, with minimal environmental impact, and with the same taste and texture you know and love. This is the promise of cell-based meat cultivation, a revolutionary approach that’s reshaping the way we think about
If you’re working with cell cultures, you already know how critical it is to monitor cell viability and growth at every stage. Whether you’re a PhD student in the middle of a crucial experiment, a seasoned scientist in biotech, or part of a cutting-edge research lab, keeping a close eye
The field of cell culture is evolving at an unprecedented pace, driving breakthroughs across biomedical research, drug discovery, and sustainable bioproducts. From 3D models revolutionizing cancer research to bioreactors scaling up production, the innovations in this space are transforming how we approach science and medicine. In 2022, the global cell
Cryopreservation is an indispensable method that underpins modern biological research and biomanufacturing. By halting biological activity through ultra-low temperature storage, cryopreservation ensures the preservation of cellular integrity, enabling long-term storage without compromising viability or functionality. This process is more than just freezing cells; it is a precise science that demands
At the heart of every successful cell-based experiment lies a simple yet powerful factor: cell culture media. Serving as the lifeblood of cells, it provides essential nutrients, growth factors, and environmental stability, acting as a surrogate microenvironment to replicate physiological conditions. Whether you’re growing mammalian cells for research, hybridomas for
Scaling up cell cultures is an art, one that bridges the gap between routine lab work and groundbreaking discoveries. Whether you’re cultivating cells for life-saving therapies, high-precision drug testing, or cutting-edge biomanufacturing, the challenge lies in achieving consistent growth while safeguarding cell viability and functionality. Efficient cell culture expansion isn’t
When it comes to cell culture, the tools you choose can make or break your workflow. Among the countless decisions researchers face, selecting the right cell culture flask might seem minor, but it’s anything but. The design of a flask—whether straight neck or angled neck—can directly impact everything from ease
With over 20 years of experience in the life science industry, we work hard to bring our customers the highest quality and most relevant products and services. We specialize in cell culture and diagnostic processed serum, cholesterol concentrates, and purified proteins.
