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GDNF is a homodimeric neurotrophic factor connected by disulfide bonds, sharing structural similarities with Artemin, Neurturin, and Persephin. These proteins are part of the cysteine-knot superfamily of growth factors, known for their stable dimeric structures. GDNF transmits signals through a complex receptor system involving RET and one of four GFRα receptors (α1-α4). Its specific actions include enhancing dopamine uptake and promoting the survival and morphological development of midbrain neurons.
In a mouse model of Parkinson’s disease, GDNF has demonstrated efficacy in improving symptoms such as bradykinesia, rigidity, and postural instability. The functional form of Human GDNF is a disulfide-linked homodimer composed of two 15 kDa polypeptide chains referred to as monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, essential for inter-chain disulfide bridging, and others that contribute to the cysteine-knot configuration, forming an intramolecular ring. The molecular weight of Recombinant Human GDNF is calculated to be 30.4 kDa.
Product Specifications
Species Human
Published species
Human, Mouse, Non-human primate
Expression System E. coli
Amino acid sequence
MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Molecular weight 30.4 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg
Activity
Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml.
Conjugate Unconjugated
Form Lyophilized
Contains
no preservative
Storage conditions -20°C
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