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The IGFs are polypeptide growth factors with mitogenic properties, stimulating cell proliferation and survival in various tissues like muscle, bone, and cartilage when studied in vitro. Although primarily produced in the liver, different tissues produce IGFs at specific times. Belonging to the Insulin gene family, which also includes insulin and relaxin, IGFs share structural and functional similarities with insulin but possess significantly stronger growth-promoting abilities. The expression of IGF-II is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone.
Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), yet IGF-II can also utilize the IGF-II/Mannose-6-phosphate receptor for signaling. Mature IGFs are formed through proteolytic processing of inactive precursor proteins that contain N-terminal and C-terminal propeptide regions. Recombinant Human IGF-I and IGF-II are globular proteins composed of 70 and 67 amino acids, respectively, with three intra-molecular disulfide bonds. The estimated molecular weight of Recombinant Human IGF-I is 7.6 kDa.
Product Specifications
Species Human
Published Species Human, Mouse, Rat, Salamander
Expression System E.coli
Amino Acid Sequence GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Molecular Weight 7.6 kDa
Class Recombinant
Type Protein
Purity ≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Concentration <0.1 EU/µg
Activity The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Conjugate Unconjugated
Form Lyophilized
Contains No Preservative
Storage -20°C
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