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$550.00
CultureGro™ Human MCSF Recombinant Protein, Animal-Free
M-CSF (Macrophage Colony-Stimulating Factor) is a powerful hematopoietic agent produced by various cell types, including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. It stands as a critical controller of the proliferation, differentiation, and survival of blood monocytes, tissue macrophages, and their precursor cells. M-CSF has demonstrated significant influence in regulating skin thickness and fertility, marking its versatility.
Clinically, M-CSF is deployed in the management of infections, cancer, and atherosclerosis, proving instrumental in hastening hematopoietic recovery following bone marrow transplants. While Human M-CSF shows efficacy in murine models, its murine counterpart does not affect human cells, highlighting species-specific responses. Recombinant Human M-CSF, a 36.8 kDa homodimeric protein, is composed of two polypeptide subunits, each with 159 amino acids, showcasing the intricate design of this biologically essential molecule.
CultureGro™ Human MCSF Recombinant Protein, Animal-Free
Species: Human
Expression System: E. coli
Amino acid sequence:
MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS
Molecular weight: 36.8 kDa
Class: Recombinant
Type: Protein
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration: <0.1 EU/µg
Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.
Conjugate: Unconjugated
Form: Lyophilized
Purification: HPLC, SDS-PAGE
Contains no preservative
Storage conditions: -20°C
CAUTION: For Research Use Only. Not for use in diagnostic procedures.
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