CultureGro™ Human BMP-2

Name: CultureGro™ Human BMP-2 - Cell Culture Collective
SKU: CultureGro™ Human BMP-2
Availability: InStock

$515.00

CultureGro™ Human BMP-2 Recombinant Protein Animal Free

BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis, and is expressed in a variety of tissues, including lung, spleen, brain, liver, prostate, ovary, and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant Human/Murine/Rat BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.

Volume

100ug
1mg
500ug
50ug

Clear

SKU CultureGro™ Human BMP-2 Categories Recombinant Proteins, TGF-Betas

Product Details

CultureGro™ Human BMP-2 Recombinant Protein Animal Free Species: Human, Mouse, Rat Published species: Human, Mouse Expression System: E. coli Amino acid sequence MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR Molecular weight: 26 kDa Class: Recombinant Type: Protein Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Endotoxin concentration: <0.1 EU/µg Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 ug/ml. Conjugate: Unconjugated Form: Lyophilized Purification: HPLC, SDS-PAGE Contains no preservative Storage conditions: -20°C CAUTION: For Research Use Only. Not for use in diagnostic procedures.

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