$650.00
IL-21, a versatile cytokine, originates from CD4+ T cells upon encountering antigens. Its primary role involves enhancing the immune system’s antigen-specific responses. IL-21 influences various immune cell activities: it fosters the transformation of T cell-activated B cells into plasma and memory B cells, boosts IgG production in tandem with IL-4, and prompts apoptosis in naive and stimulated B cells without T cell input. Furthermore, IL-21 bolsters the anti-tumor functions of CD8+ T cells and natural killer (NK) cells.
To execute its functions, IL-21 binds to the IL-21R, a type I cytokine receptor that includes the γ chain (γc) shared with other cytokine receptors like IL-2, IL-4, IL-7, IL-9, and IL-15. This interaction sets off a chain reaction involving JAK1 and JAK3 tyrosine kinases’ activation, ultimately leading to STAT1 and STAT3 transcription factor activation.
The recombinant Human IL-21, a 15.4 kDa protein composed of 132 amino acids, mirrors these biological activities.
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