$534.00
PDGFs exist as disulfide-linked dimers comprising two polypeptide chains, PDGF-A and PDGF-B, each weighing between 12.0 and 13.5 kDa. Among the three naturally occurring PDGFs—PDGF-AA, PDGF-BB, and PDGF-AB—all are potent mitogens affecting various cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain blood cells. These growth factors are stored in platelet α-granules and released upon platelet activation, contributing to processes like hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development.
PDGFs engage two distinct signaling receptors known as PDGFR-α and PDGFR-β. PDGFR-α serves as a high-affinity receptor for all three PDGF forms, while PDGFR-β selectively interacts with PDGF-BB and PDGF-AB. Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer consisting of two A chains, totaling 250 amino acids.
With over 20 years of experience in the life science industry, we work hard to bring our customers the highest quality and most relevant products and services. We specialize in cell culture and diagnostic processed serum, cholesterol concentrates, and purified proteins.
