Originally identified as IL-17 and now referred to as IL-17A, this protein is a homodimer consisting of two 136 amino acid chains. It is released by activated T-cells and acts on stromal cells, triggering the production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 encompasses a family of structurally-related cytokines with a highly conserved C-terminal region. However, they vary in their N-terminal regions and exhibit distinct biological functions. The family includes six members known as IL-17A through IL-17F, all of which are secreted as homodimers.
Of note, IL-17A demonstrates bioactivity across species, showing effectiveness in both Human and murine cells. The recombinant Human IL-17A is a 31.3 kDa disulfide-linked homodimer composed of two 137 amino acid polypeptide chains.
$376.00 – $3,100.00
Product Specifications
Species Human
Published species
Bovine, Human, Mouse
Expression System E. coli
Amino acid sequence
MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
Molecular weight 31.3 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg
Activity
Measured by its ability to induce IL-6 production by NHDF cells using a concentration range of 0.5-1.5 ng/ml.
Conjugate Unconjugated
Form Lyophilized
Contains
no preservative
Storage conditions -20°C
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