IL-21, a versatile cytokine, originates from CD4+ T cells upon encountering antigens. Its primary role involves enhancing the immune system’s antigen-specific responses. IL-21 influences various immune cell activities: it fosters the transformation of T cell-activated B cells into plasma and memory B cells, boosts IgG production in tandem with IL-4, and prompts apoptosis in naive and stimulated B cells without T cell input. Furthermore, IL-21 bolsters the anti-tumor functions of CD8+ T cells and natural killer (NK) cells.
To execute its functions, IL-21 binds to the IL-21R, a type I cytokine receptor that includes the γ chain (γc) shared with other cytokine receptors like IL-2, IL-4, IL-7, IL-9, and IL-15. This interaction sets off a chain reaction involving JAK1 and JAK3 tyrosine kinases’ activation, ultimately leading to STAT1 and STAT3 transcription factor activation.
The recombinant Human IL-21, a 15.4 kDa protein composed of 132 amino acids, mirrors these biological activities.
$650.00 – $5,500.00
Product Specifications
Species Human
Published species
Human, Mouse
Expression System E. coli
Amino acid sequence
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
Molecular weight 15.4 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg
Activity
Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x10^6 units/mg.
Conjugate Unconjugated
Form Lyophilized
Contains
no preservative
Storage conditions -20°C
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