NT-4 is a neurotrophic factor sharing structural similarities with β-NGF, BDNF, and NT-3, all part of the cysteine-knot family of growth factors characterized by stable dimeric structures. It is expressed in various tissues such as the prostate, thymus, placenta, and skeletal muscle. NT-4 can activate signaling pathways through the LNGFR and trkB receptors, leading to the survival of peripheral sensory sympathetic neurons. Recombinant Human NT-4 exists as a noncovalently linked homodimer comprising two 14.0 kDa polypeptide monomers, totaling 260 amino acid residues.
$644.00 – $5,300.00
Product Specifications
Species Human
Published species Human
Expression System E. coli
Amino acid sequence
GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA
Molecular weight 28.1 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <1 EU/µg
Activity
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Conjugate Unconjugated
Form Lyophilized
Contains
no preservative
Storage conditions -20°C
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