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CultureGro™ Human SCF

CultureGro™ Human SCF

SCF, a hematopoietic growth factor, functions by activating the c-Kit receptor. This interaction is crucial for the survival, proliferation, and differentiation of hematopoietic cells committed to melanocyte and germ cell lineages. Interestingly, Human SCF has limited activity on murine cells, whereas murine and rat SCF are fully functional on Human cells.

The Human SCF gene encodes a 273 amino acid transmembrane protein, consisting of a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. The soluble form of SCF is produced by proteolytic cleavage of the membrane-anchored precursor.

Recombinant Human SCF is an 18.4 kDa polypeptide comprising 165 amino acid residues, representing the sequence of the secreted soluble form of SCF.

$300.00$2,500.00

SKU CultureGro™ Human SCF Categories ,

Product Details

Product Specifications

Species Human
Published species
Human, Mouse, Rabbit
Expression System E. coli
Amino acid sequence
MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA
Molecular weight 18.4 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg Activity The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg. Conjugate Unconjugated Form Lyophilized Contains no preservative Storage conditions -20°C